• Acute infection as a trigger for incident venous thromboembolism: Results from a population- based case- crossover study 

      Grimnes, Gro; Isaksen, Trond; Tichelaar, Ynse Ieuwe Gerardus Vladimir; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-21)
      Background:<br> A bidirectional relation exists between acute infection and immobilization, and both are triggers for venous thromboembolism (VTE). To what extent the association between infection and VTE‐risk is explained by immobilization is unknown. <br>Aims:<br> To investigate the impact of hospitalization with acute infection on the VTE‐risk in patients with and without concomitant ...
    • C-reactive protein and risk of venous thromboembolism: Results from a population-based case-crossover study 

      Grimnes, Gro; Isaksen, Trond; Tichelaar, Ynse Ieuwe Gerardus Vladimir; Brox, Jan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-19)
      Long-term, low-grade inflammation does not seem to be a risk factor for venous thromboembolism. The impact of acute inflammation, regardless of cause, on risk of venous thromboembolism is scarcely studied. We aimed to investigate the impact of acute inflammation, assessed by C-reactive protein, on short-term risk of venous thromboembolism. We conducted a case-crossover study of patients with venous ...
    • Fra lokalt til nasjonalt utbrudd av Pseudomonas aeruginosa 

      Asfeldt, anne mette; Myrbakk, Torni; Grimnes, Gro; Kildal, Anders Benjamin; Pedersen, Torunn Annie; Littauer, Pia; Bogetvedt, Tina; Kroken, Bjørn Anders; Nerskogen, Birgith Jørgensen; Høgli, June Utnes; Åsheim, Sandra Elena (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-29)
      Utbrudd som rammer flere sykehus, krever god koordinering. Folkehelseinstituttets rolle i dette arbeidet bør styrkes, og vi trenger bedre systemer for utbruddsovervåking, rask tilgang til genteknologiske verktøy samt metoder for mikrobiologiske undersøkelser av miljø og utstyr.
    • Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial 

      Grimnes, Gro; Bhoelan, Soerajja; Hindberg, Kristian; Davids, Mark; Nieuwdorp, Max; Mollnes, Tom E.; Michelsen, Annika Elisabet; Ueland, Thor; Brækkan, Sigrid K.; Hansen, John-Bjarne; Tichelaar, Ynse Ieuwe Gerardus Vladimir (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-24)
      Rationale - Inflammation is present in several conditions associated with risk of venous thromboembolism. The gut microbiome might be a source of systemic inflammation and activation of coagulation, by translocation of lipopolysaccharides from gram-negative bacteria to the systemic circulation.<p> <p>Objective - To investigate whether a vancomycin-induced shift of the gut microbiome in a gram-negative ...
    • Infection, inflammation, and risk of venous thromboembolism 

      Grimnes, Gro (Doctoral thesis; Doktorgradsavhandling, 2018-06-18)
      SUMMARY Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is the third most common cardiovascular disease after myocardial infarction and stroke. The incidence of VTE is increasing and VTE contributes to a substantial burden of morbidity and mortality. To be able to prevent VTE in vulnerable subjects, there is a need for more knowledge about the pathophysiology ...
    • Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study 

      Sejrup, Joakim Knutsen; Børvik, Trond; Grimnes, Gro; Isaksen, Trond; Hindberg, Kristian; Hansen, John-Bjarne; Morelli, Vania Maris; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-16)
      Patients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors into account. We conducted a case–crossover study of VTE patients (<i>n</i> = 707) recruited from the ...
    • The Role of Stroke as a Trigger for Incident Venous Thromboembolism: Results from a Population-based Case-Crossover Study 

      Morelli, Vania Maris; Sejrup, Joakim Knutsen; Småbrekke, Birgit; Rinde, Ludvig B; Grimnes, Gro; Isaksen, Trond; Hansen, John-Bjarne; Hindberg, Kristian; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-22)
      Stroke is associated with a short-term increased risk of subsequent venous thromboembolism (VTE). It is unclear to what extent this association is mediated by strokerelated complications that are potential triggers for VTE, such as immobilization and infection. We aimed to investigate the role of acute stroke as a trigger for incident VTE while taking other concomitant VTE triggers into account. ...